Luke McCloud’s practice focuses on complex civil matters, with an emphasis on patent litigation.  He also represents clients in connection with white collar criminal defense matters.  Luke has represented corporations and individuals as trial counsel in a broad range of substantive areas of litigation, including contract disputes, intellectual property, securities and derivative litigation, and professional liability matters.  

Luke is also an experienced appellate litigator, having argued or briefed dozens of high-stakes appeals throughout the federal system, including at the U.S. Supreme Court.  His appellate oral advocacy was praised by The Recorder as “poised and polished.”  Luke has been recognized by The Legal 500 as a Rising Star—General Commercial Disputes (2020 and 2021) and by Managing IP as a Rising Star (2020).    

A native of eastern Kentucky, Luke earned a B.S. in Aerospace Engineering from the Georgia Institute of Technology, and a J.D. from Harvard Law School, where he was Vice President & Treasurer of the Harvard Law Review and a finalist in the Ames Moot Court Competition.  Luke joined Williams & Connolly in 2012. He currently serves as a member of the firm’s Hiring and Pro Bono Committees, and was previously a member of the Diversity and Inclusion Committee. In the October Term 2014, Luke served as a law clerk to Justice Sonia M. Sotomayor on the United States Supreme Court.  He previously clerked for Judge Brett M. Kavanaugh of the United States Court of Appeals for the District of Columbia Circuit and Judge Paul V. Niemeyer of the United States Court of Appeals for the Fourth Circuit. Luke maintains an active pro bono practice focusing on veterans’ causes, landlord-tenant matters, and education initiatives. 

Representative Experience

  • Trial and appellate counsel for biopharmaceutical company in BPCIA dispute.
  • Trial counsel for multinational diagnostics company in patent dispute.
  • Trial counsel for pharmaceutical company in multi-district antitrust litigation
  • Successfully argued appeal in the U.S. Court of Appeals for the Second Circuit, obtaining affirmance of district court’s dismissal of $300 million tort and fraud claims against pharmaceutical company.
  • Successfully argued in the U.S. Court of Appeals for the Federal Circuit, obtaining vacatur of order denying writ of mandamus filed by veteran’s widow.
  • Successfully defended multiple appeals on behalf of pharmaceutical company in Hatch-Waxman litigation involving an anti-cancer treatment.
  • Appellate counsel for Fortune 500 company before the U.S. Supreme Court and Fifth Circuit in arbitration dispute.
  • Trial counsel for biopharmaceutical company in contract dispute regarding intellectual property and joint venture agreement.
  • Counsel for major bank in connection with criminal investigation relating to alleged financial reporting issues.
  • Counsel for pharmaceutical company in a securities fraud class action.




"Rising Star" for General Commercial Disputes, The Legal 500, 2020-2021


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